Perspectives to Fight Viruses. The Example of Sars-CoV-2

By Costas Demetzos (Professor of Pharmaceutical Technology and Nanotechnology, NKUA), Panagiotis Vlamos (Professor, Ionian University) and Dimitrios Vlachakis (Assistan Professor, Agricultural University of Athens)

The article is available at the website of the Proceedings of the European Academy of Sciences and Arts, PEASA

Article Link: https://www.peasa.eu/perspectives-to-fight-viruses-the-example-of-sars-cov-2/

Abstract

Coronaviruses well studied in the past provide scientific tools and knowledge that is used for identifying the molecular basis of the new SARS-CoV-2. It belongs to complex systems and its evolution and mutations must be observed under the lens of the nonlinearity as it is far from the equilibrium conditions. The new properties that SARS-CoV-2 carries were incubated for a long time in microcosm refining its information content. Various animal species acted as transmitters of SARS-CoV-2 to human beings. In this perspective article, we argue that the infection ability of the new virus can correlate with its thermodynamic payload. Design: We suggest that by identifying the thermodynamic content and biophysical profile of the viruses’ proteins using a mathematical framework of nonlinear complex systems, we can simulate its molecular origin and design weapons for fighting it. We suggest discovering for artificial ‘decision-making’ nano-platforms that can decrypt the ‘crypted information code’ of viruses that permit their mutation process taking place not randomly but based on the self-assembly process of its nucleotides following the micro and macro environmental conditions. Main outcomes: Our proposition is to design nanoplatforms (decision making nanocarriers) that can carry thermodynamic variables that could interrupt the mutations, virulence, and proliferation. This approach is innovative and is a challenge that should be checked in the future. This concept needs generous funding by governments for supporting intelligence and innovative research projects. Mainly, we need solidarity between nations to shield the health of societies.

The authors of the article in their research conclusions state:

(…) our strong belief is that: virus attacks on the level of information. We should be ready to manage and quickly decode virus’s information and to develop as quickly as possible digital tools, protocols, and nano-platforms for therapeutic purposes to fight viruses. The governments and the nations should be sensitive and informed regarding such an ‘information war’.