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NKUA: Pioneering research by Professor V. Gorgoulis and his collaborators on the detection and isolation of senescent cells

NKUA: Pioneering research by Professor V. Gorgoulis and his collaborators on the detection and isolation of senescent cells
12.10.2023 - 16.49
gorgoulis

Professor of NKUA Vassilis Gorgoulis and his collaborators published on 5 October 2023 in the international and highly prestigious scientific journal Molecular Cell a pioneering research on the detection and isolation of senescent cells.

A fluorophore-conjugated reagent enabling rapid detection, isolation, and live tracking of senescent cells:

https://www.cell.com/molecular-cell/fulltext/S1097-2765(23)00703-7

Since cellular senescence is involved in numerous diseases, the authors present a pioneering and innovative chemical compound (GLF16) as a marker for the special tracking and imaging of senescent cells in various biological materials. A distinctive characteristic of the GLF16 marker is that it allows for the first time the detection of senescent cells at the level of living tissues and organisms. More importantly, it enables the selective isolation of live senescent cells, opening the door for the first time to their precise characterization at various levels, particularly those of the genome and epigenome, and, ultimately, to the development of personalized treatments in pathological fields where cellular senescence is involved.

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University of Athens

The National and Kapodistrian University of Athens, which was inaugurated on May 3, 1837, was initially housed in a renovated Ottoman building on the northeastern side of the Acropolis. This building has since been restored and now functions as the University Museum. Originally named the "Othonian University," after Otto, the first king of Greece, it consisted of four academic departments and 52 students. As the first university of the newly established Greek state, as well as of the broader Balkan and Mediterranean region, it assumed an important socio-historical role, which was pivotal in the development of specific forms of knowledge and culture within the country.

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